Osteonecrosis of the hip in hematologic disease: A review of conditions and treatment options

Megan M. Sorich, Jeffrey J. Cherian, Mark J. McElroy, Samik Banerjee, Lynne C. Jones, Caterina P. Minniti, Michael A. Mont

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Osteonecrosis of the hip can lead to advanced arthritis in typically young patients. Hematologic disorders comprise one group of potential causes. These include sickle cell anemia, hemophilia, aplastic anemia, thalassemia, and acute lymphoblastic leukemia. Depending on the stage of disease, treatment options include non-operative management, joint-preserving procedures (percutaneous drilling, core decompression, and vascularized or non-vascularized bone grafting), and joint arthroplasty (resurfacing arthroplasty and THA). Numerous small studies have investigated the efficacy of these options in patients who have specific hematologic disorders. Therefore, this report provides a comprehensive review of the osteonecrosis treatment options and results across the spectrum of patients who have various hematologic disorders.

Original languageEnglish (US)
Pages (from-to)253-268
Number of pages16
JournalJournal of Long-Term Effects of Medical Implants
Issue number4
StatePublished - 2015
Externally publishedYes


  • Anemia
  • Hemophilia
  • Hip
  • Osteonecrosis
  • Sickle cell
  • Total hip arthroplasty

ASJC Scopus subject areas

  • Biomedical Engineering
  • General Dentistry


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