Abstract
Orphan nuclear receptors regulate diverse biological processes. These important molecules are ligand-activated transcription factors that act as natural sensors for a wide range of steroid hormones and xenobiotic ligands. Because of their importance in regulating various novel signaling pathways, recent research has focused on identifying xenobiotics targeting these receptors for the treatment of multiple human diseases. In this review, we will highlight these receptors in several physiologic and pathophysiologic actions and demonstrate how their functions can be exploited for the successful development of newer drugs.
Original language | English (US) |
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Pages (from-to) | 1439-1468 |
Number of pages | 30 |
Journal | Pharmaceutical Research |
Volume | 27 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2010 |
Keywords
- agonist
- antagonist
- ligand binding domain
- orphan nuclear receptor
ASJC Scopus subject areas
- Biotechnology
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Organic Chemistry
- Pharmacology (medical)