Optimizing pain management following kidney stone surgery: can we avoid narcotics?

Matthew Demasi, Michal Segall, Amanda Mengotto, Pablo Cuartas, Nathan Feiertag, Justin Loloi, Jordan Ahn, Mimi Kim, Melissa Laudano, Joshua Stern, Kara Watts

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Introduction: Opioids are often used to manage postoperative pain. Non-narcotic alternatives have increasingly been used to reduce opioid usage. We conducted an open-label randomized non-inferiority clinical trial to compare non-opioid to opioid therapy for pain management after nephrolithiasis surgery. Methods: Patients undergoing elective ureteroscopy or percutaneous nephrolithotomy between July 2018 and May 2021 were randomized to receive ketorolac (non-opioid) or oxycodone-acetaminophen (opioid). Each patient was surveyed one week postoperatively to assess pain outcomes. Patient demographics, surgical variables, number of pills used, constipation, and adverse events were also assessed. We evaluated whether non-opioid analgesia was non-inferior to opioid analgesia for postoperative pain, assuming a non-inferiority margin of 1.3 in pain score between groups. Results: Analyses were based on 90 patients with postoperative pain data: 44 in the ketorolac group and 46 in the oxycodone-acetaminophen group. The groups were similar regarding demographics, type of surgery, ureteral stent placement, and stone burden. Non-inferiority of non-opioids compared to opioids was demonstrated for all outcomes. At follow-up, the average pain scores were 3.20 ± 1.94 (SD) in the non-opioid group and 4.17 ± 1.84 in the opioid group (difference = − 0.96; 95% CI: − 1.76, − 0.17, p = 0.018). The mean proportions of unused pills were similar between groups (p = 0.47) as were rates of constipation (p = 0.32). Conclusions: Non-opioid analgesia was non-inferior to opioid analgesia in pain management after kidney stone surgery. This trial contributes to the evidence that non-opioid analgesics should be considered an effective option for pain management following non-invasive urologic procedures.

Original languageEnglish (US)
Pages (from-to)3061-3066
Number of pages6
JournalWorld Journal of Urology
Issue number12
StatePublished - Dec 2022


  • NSAIDs
  • Nephrolithiasis
  • Opioids
  • PCNL
  • URS

ASJC Scopus subject areas

  • Urology


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