Abstract
(Equation Presented) The syntheses of two epothilone analogues, 15(S)-aza-12,13-desoxyepothilone B and the epimeric 15(R)-aza-12,13-desoxyepothilone B, are described. A Mitsunobu inversion was utilized for elaboration of pre-epothilone fragments to the corresponding macrolactam. Tubulin binding and cytotoxicity profiles of these analogues are presented.
Original language | English (US) |
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Pages (from-to) | 1637-1639 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 2 |
Issue number | 11 |
DOIs | |
State | Published - Jun 1 2000 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry