On the role of retrosplenial cortex in long-lasting memory storage

Cynthia Katche; Guido Dorman; Carolina Gonzalez; Cecilia P. Kramar; Leandro Slipczuk; Janine I. Rossato; Martin Cammarota; Jorge H. Medina

doi:10.1002/hipo.22092

On the role of retrosplenial cortex in long-lasting memory storage

Cynthia Katche, Guido Dorman, Carolina Gonzalez, Cecilia P. Kramar, Leandro Slipczuk, Janine I. Rossato, Martin Cammarota, Jorge H. Medina

Medicine

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement in memory processing is unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis and c-Fos expression in the anterior part of RSC (aRSC) are necessary late after training to maintain for many days a fear-motivated memory. Long-lasting memory storage is regulated by D1/D5 dopamine receptors in aRSC and depends on the functional interplay between dorsal hippocampus and aRSC. These results suggest that the RSC recapitulates some of the molecular events that occur in the hippocampus to maintain memory trace over time.

Original language	English (US)
Pages (from-to)	295-302
Number of pages	8
Journal	Hippocampus
Volume	23
Issue number	4
DOIs	https://doi.org/10.1002/hipo.22092
State	Published - Apr 2013

Keywords

C-Fos
Dopamine
Hippocampus
Memory persistence
Protein synthesis

ASJC Scopus subject areas

Cognitive Neuroscience

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10.1002/hipo.22092

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abstract = "The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement in memory processing is unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis and c-Fos expression in the anterior part of RSC (aRSC) are necessary late after training to maintain for many days a fear-motivated memory. Long-lasting memory storage is regulated by D1/D5 dopamine receptors in aRSC and depends on the functional interplay between dorsal hippocampus and aRSC. These results suggest that the RSC recapitulates some of the molecular events that occur in the hippocampus to maintain memory trace over time.",

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AU - Dorman, Guido

AU - Gonzalez, Carolina

AU - Kramar, Cecilia P.

AU - Slipczuk, Leandro

AU - Rossato, Janine I.

AU - Cammarota, Martin

AU - Medina, Jorge H.

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AB - The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement in memory processing is unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis and c-Fos expression in the anterior part of RSC (aRSC) are necessary late after training to maintain for many days a fear-motivated memory. Long-lasting memory storage is regulated by D1/D5 dopamine receptors in aRSC and depends on the functional interplay between dorsal hippocampus and aRSC. These results suggest that the RSC recapitulates some of the molecular events that occur in the hippocampus to maintain memory trace over time.

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KW - Memory persistence

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On the role of retrosplenial cortex in long-lasting memory storage

Abstract

Keywords

ASJC Scopus subject areas

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