On the role of retrosplenial cortex in long-lasting memory storage

Cynthia Katche, Guido Dorman, Carolina Gonzalez, Cecilia P. Kramar, Leandro Slipczuk, Janine I. Rossato, Martin Cammarota, Jorge H. Medina

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement in memory processing is unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis and c-Fos expression in the anterior part of RSC (aRSC) are necessary late after training to maintain for many days a fear-motivated memory. Long-lasting memory storage is regulated by D1/D5 dopamine receptors in aRSC and depends on the functional interplay between dorsal hippocampus and aRSC. These results suggest that the RSC recapitulates some of the molecular events that occur in the hippocampus to maintain memory trace over time.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
Issue number4
StatePublished - Apr 2013


  • C-Fos
  • Dopamine
  • Hippocampus
  • Memory persistence
  • Protein synthesis

ASJC Scopus subject areas

  • Cognitive Neuroscience


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