On the role of ischemia in the pathogenesis of IBD: A review

Christopher B. Ibrahim, Olga C. Aroniadis, Lawrence J. Brandt

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Inflammatory bowel disease (IBD) is a chronic intestinal disorder comprising 2 distinct but often overlapping diseases: Crohn's disease and ulcerative colitis. Although much research to identify the etiology of IBD has focused on genetic constitution, infectious causes, and immune dysregulation, its exact cause and pathogenesis remain incompletely understood. Mesenteric blood flow, the intestinal microcirculation, and intestinal ischemia also have been proposed as etiologic, although they remain less-explored themes despite evidence suggesting a contributory role in IBD pathogenesis. The anatomy, architecture, and function of the splanchnic microcirculation will be reviewed here with regard to the development of intestinal microvascular ischemia, a pathologic process that appears to precede the classic changes that characterize IBD.

Original languageEnglish (US)
Pages (from-to)696-702
Number of pages7
JournalInflammatory bowel diseases
Issue number4
StatePublished - Apr 1 2010


  • Crohn's disease
  • Ischemia
  • Ulcerative colitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology


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