Olfactory bulbectomy induced oxidative and cell damage in rat: Protective effect of melatonin

I. Tasset; F. J. Medina; J. Peña; I. Jimena; M. del Carmen muñoz; M. Salcedo; C. Ruiz; M. Feijóo; P. Montilla; I. Túnez

Olfactory bulbectomy induced oxidative and cell damage in rat: Protective effect of melatonin

I. Tasset, F. J. Medina, J. Peña, I. Jimena, M. del Carmen muñoz, M. Salcedo, C. Ruiz, M. Feijóo, P. Montilla, I. Túnez

Research output: Contribution to journal › Article › peer-review

Abstract

In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.

Original language	English (US)
Pages (from-to)	105-112
Number of pages	8
Journal	Physiological Research
Volume	59
Issue number	1
State	Published - 2010
Externally published	Yes

Keywords

Antioxidant
Depression
Melatonin
Olfactory bulbectomy
Oxidative stress

ASJC Scopus subject areas

Physiology

Cite this

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abstract = "In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.",

keywords = "Antioxidant, Depression, Melatonin, Olfactory bulbectomy, Oxidative stress",

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T1 - Olfactory bulbectomy induced oxidative and cell damage in rat

T2 - Protective effect of melatonin

AU - Tasset, I.

AU - Medina, F. J.

AU - Peña, J.

AU - Jimena, I.

AU - muñoz, M. del Carmen

AU - Salcedo, M.

AU - Ruiz, C.

AU - Feijóo, M.

AU - Montilla, P.

AU - Túnez, I.

PY - 2010

Y1 - 2010

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AB - In this study we analyzed the effects of melatonin (Mel, 1 mg/kgip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations.

KW - Antioxidant

KW - Depression

KW - Melatonin

KW - Olfactory bulbectomy

KW - Oxidative stress

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Olfactory bulbectomy induced oxidative and cell damage in rat: Protective effect of melatonin

Abstract

Keywords

ASJC Scopus subject areas

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