Occurrence of Adenovirus-SV40 Hybrids Among Monkey Kidney Cell Adapted Strains of Adenovirus

Andrew M. Lewis; Stephen G. Baum; Kirsten O. Prigge; Wallace P. Rowe

doi:10.3181/00379727-122-31093

Occurrence of Adenovirus-SV40 Hybrids Among Monkey Kidney Cell Adapted Strains of Adenovirus

Andrew M. Lewis, Stephen G. Baum, Kirsten O. Prigge, Wallace P. Rowe

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Abstract

The strains of adenovirus types 1 through 5 adapted to rhesus monkey kidney cultures for use in vaccines became contaminated with SV40 virus and formed hybrids, carrying SV40 genetic material in adenovirus capsids in a manner similar to that seen in Ad. 7 strain LLE46. The ability of the strains studied here to propagate in monkey cells (with the possible exception of type 5) is dependent on the SV40 genetic material and is not due to emergence of monkey-adapted adenovirus mutants.

Original language	English (US)
Pages (from-to)	214-218
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	122
Issue number	1
DOIs	https://doi.org/10.3181/00379727-122-31093
State	Published - May 1966
Externally published	Yes

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Biochemistry, Genetics and Molecular Biology(all)

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10.3181/00379727-122-31093

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AB - The strains of adenovirus types 1 through 5 adapted to rhesus monkey kidney cultures for use in vaccines became contaminated with SV40 virus and formed hybrids, carrying SV40 genetic material in adenovirus capsids in a manner similar to that seen in Ad. 7 strain LLE46. The ability of the strains studied here to propagate in monkey cells (with the possible exception of type 5) is dependent on the SV40 genetic material and is not due to emergence of monkey-adapted adenovirus mutants.

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Occurrence of Adenovirus-SV40 Hybrids Among Monkey Kidney Cell Adapted Strains of Adenovirus

Abstract

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