Occupational exposure to trichloroethylene and serum concentrations of IL-6, IL-10, and TNF-alpha

Bryan A. Bassig, Luoping Zhang, Xiaojiang Tang, Roel Vermeulen, Min Shen, Martyn T. Smith, Chuangyi Qiu, Yichen Ge, Zhiying Ji, Boris Reiss, H. Dean Hosgood, Songwang Liu, Rachel Bagni, Weihong Guo, Mark Purdue, Wei Hu, Fei Yue, Laiyu Li, Hanlin Huang, Nathaniel RothmanQing Lan

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


To evaluate the immunotoxicity of trichloroethylene (TCE), we conducted a cross-sectional molecular epidemiology study in China of workers exposed to TCE. We measured serum levels of IL-6, IL-10, and TNF-α, which play a critical role in regulating various components of the immune system, in 71 exposed workers and 78 unexposed control workers. Repeated personal exposure measurements were taken in workers before blood collection using 3 M organic vapor monitoring badges. Compared to unexposed workers, the serum concentration of IL-10 in workers exposed to TCE was decreased by 70% (P=0.001) after adjusting for potential confounders. Further, the magnitude of decline in IL-10 was >60% and statistically significant in workers exposed to <12 ppm as well as in workers with exposures ≥ 12 ppm of TCE, compared to unexposed workers. No significant differences in levels of IL-6 or TNF-α were observed among workers exposed to TCE compared to unexposed controls. Given that IL-10 plays an important role in immunologic processes, including mediating the Th1/Th2 balance, our findings provide additional evidence that TCE is immunotoxic in humans.

Original languageEnglish (US)
Pages (from-to)450-454
Number of pages5
JournalEnvironmental and Molecular Mutagenesis
Issue number6
StatePublished - Jul 2013


  • IL-10
  • IL-6
  • Immunotoxicity
  • Occupational exposure
  • TNF-α
  • Trichloroethylene

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis


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