TY - JOUR
T1 - Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory
AU - Grober, Ellen
AU - Schaumburg, Herbert H.
PY - 2000/5/9
Y1 - 2000/5/9
N2 - The authors describe serial evaluations of a 44-year-old man who became cognitively impaired during a 6-year period of repeated exposure to high levels of methyl isobutyl ketone (MIBK). Neuropsychological tests administered six times over 10 years demonstrated a stable pattern of cognitive impairment. Dynamic imaging studies suggested persistent CNS dysfunction. The authors conclude that chronic, high-level, occupational MIBK exposure can cause a persistent cognitive syndrome best explained by impaired working memory.
AB - The authors describe serial evaluations of a 44-year-old man who became cognitively impaired during a 6-year period of repeated exposure to high levels of methyl isobutyl ketone (MIBK). Neuropsychological tests administered six times over 10 years demonstrated a stable pattern of cognitive impairment. Dynamic imaging studies suggested persistent CNS dysfunction. The authors conclude that chronic, high-level, occupational MIBK exposure can cause a persistent cognitive syndrome best explained by impaired working memory.
KW - Cognitive dysfunction
KW - Methyl isobutyl ketone
KW - Occupational exposure
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=0034624933&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034624933&partnerID=8YFLogxK
U2 - 10.1212/WNL.54.9.1853
DO - 10.1212/WNL.54.9.1853
M3 - Article
C2 - 10802798
AN - SCOPUS:0034624933
SN - 0028-3878
VL - 54
SP - 1853
EP - 1855
JO - Neurology
JF - Neurology
IS - 9
ER -