TY - JOUR
T1 - Obstructive sleep apnea and world trade center exposure
AU - Glaser, Michelle S.
AU - Shah, Neomi
AU - Webber, Mayris P.
AU - Zeig-Owens, Rachel
AU - Jaber, Nadia
AU - Appel, David W.
AU - Hall, Charles B.
AU - Weakley, Jessica
AU - Cohen, Hillel W.
AU - Shulman, Lawrence
AU - Kelly, Kerry
AU - Prezant, David
PY - 2014/10/8
Y1 - 2014/10/8
N2 - Objectives: Todescribe the proportion of at-risk World Trade Center (WTC)-exposed rescue/recovery workers with polysomnogram-confirmed obstructive sleep apnea (OSA) and examine the relationship between WTC ex-posure, physician-diagnosed gastroesophageal reflux disease (GERD), and rhinosinusitis and OSA.Methods: A total of 636 male participants com-pleted polysomnography from September 24, 2010, to September 23, 2012. Obstructive sleep apnea was classified as mild, moderate, or severe. Associations were tested using nominal polytomous logistic regression.Results: Eighty-one percent of workers were diagnosed with OSA. Using logistic regression models, severe OSA was associated with WTC exposure on September 11, 2001 (odds ratio, 1.91; 95% confidence interval, 1.15 to 3.17), GERD (odds ratio, 2.75; 95% confidence interval, 1.33 to 5.70), and comorbid GERD/rhinosinusitis (odds ratio, 2.31; 95% confidence interval, 1.22 to 4.40).Conclusions: We found significant associations between severe OSA and WTC exposure, and with diseases prevalent in this population. Accordingly, we recommend clinical evaluation, including polysomnogra-phy, for patients with high WTC exposure, other OSA risk factors, and a physician diagnosis of GERD or comorbid GERD and rhinosinusitis.
AB - Objectives: Todescribe the proportion of at-risk World Trade Center (WTC)-exposed rescue/recovery workers with polysomnogram-confirmed obstructive sleep apnea (OSA) and examine the relationship between WTC ex-posure, physician-diagnosed gastroesophageal reflux disease (GERD), and rhinosinusitis and OSA.Methods: A total of 636 male participants com-pleted polysomnography from September 24, 2010, to September 23, 2012. Obstructive sleep apnea was classified as mild, moderate, or severe. Associations were tested using nominal polytomous logistic regression.Results: Eighty-one percent of workers were diagnosed with OSA. Using logistic regression models, severe OSA was associated with WTC exposure on September 11, 2001 (odds ratio, 1.91; 95% confidence interval, 1.15 to 3.17), GERD (odds ratio, 2.75; 95% confidence interval, 1.33 to 5.70), and comorbid GERD/rhinosinusitis (odds ratio, 2.31; 95% confidence interval, 1.22 to 4.40).Conclusions: We found significant associations between severe OSA and WTC exposure, and with diseases prevalent in this population. Accordingly, we recommend clinical evaluation, including polysomnogra-phy, for patients with high WTC exposure, other OSA risk factors, and a physician diagnosis of GERD or comorbid GERD and rhinosinusitis.
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U2 - 10.1097/JOM.0000000000000283
DO - 10.1097/JOM.0000000000000283
M3 - Article
C2 - 25285973
AN - SCOPUS:84915781748
SN - 1076-2752
VL - 56
SP - S30-S34
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
ER -
