Observations on the development of the weaver mouse cerebellum

Asao Hirano, Herbert M. Dembitzer

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


The cerebellar cortices of young weaver mice were examined by electron microscopy and compared with those of normal littcrmatcs. Unattached dendritic spines arising from Purkinjc cells, very much like those previously described in the adult weaver, were found by the eleventh day after birth. Granule cell degeneration was seen but no examples of degeneration of presynaptic structures could be detected. Unlike cither the adult weaver or the developing normal mouse, symmetrical junctions between dendritic spines were present, as were asymmetrical junctions between Purkinjc cell dendritic spines and nonspc-cialized regions of the surface of external granule cell soma. The mechanism of formation of the unattached spines is discussed.

Original languageEnglish (US)
Pages (from-to)354-364
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Issue number3
StatePublished - Jul 1974

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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