O-Glycans in Mammalian Notch Signaling

Research output: Chapter in Book/Report/Conference proceedingChapter


Notch signaling occurs following the activation of membrane-bound Notch receptors by canonical Notch ligands expressed in neighboring cells. It is a fundamental requirement for the regulation of cell fate decisions during organellar differentiation in mammals. The extracellular domain of Notch receptors comprises numerous epidermal growth factor-like (EGF) repeats, many of which are modified by glycans O-linked to Ser or Thr at specific consensus sites. This chapter will summarize the nature and functions of O-Fucose, O-Glucose, O-GlcNAc, and O-GalNAc glycans in mammalian cells, mouse development, and human disease. Congenital diseases that arise from reduced addition of O-glycans reveal the importance of these modifications for Notch signaling.

Original languageEnglish (US)
Title of host publicationGlycoscience
Subtitle of host publicationBiology and Medicine
PublisherSpringer Japan
Number of pages8
ISBN (Electronic)9784431548416
ISBN (Print)9784431548409
StatePublished - Jan 1 2015


  • Notch ligands
  • Notch receptors
  • Notch signaling
  • O-Fucose
  • O-GalNAc
  • O-GlcNAc
  • O-Glucose
  • O-glycans

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine


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