Nucleus raphe dorsalis in parkinsonism-dementia complex of Guam

T. Yamamoto, A. Hirano

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Recently, morphometric analysis has shown that the nucleus raphe dorsalis, which is presumed to project diffuse serotonergic fibers to the telencephalon, is affected in Alzheimer's disease. A similar study was conducted in this report in two patients with parkinsonism-dementia complex of Guam and a Guamanian control. It demonstrated a significant reduction in the number of large neurons, and the presence of abundant Alzheimer's neurofibrillary tangles in this nucleus.

Original languageEnglish (US)
Pages (from-to)296-299
Number of pages4
JournalActa Neuropathologica
Issue number3-4
StatePublished - Sep 1 1985


  • Alzheimer's disease
  • Morphometry
  • Neurofibrillary tangles
  • Nucleus raphe dorsalis
  • Parkinsonism-dementia complex of Guam

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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