Nuclear protein in testis midline carcinoma of larynx: An underdiagnosed entity

Ajay Kundra, Mirela Andrei, William Westra, Rashid Chaudhry, Harry Moussouris, Arash Gohari, Jen C. Wang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: Nuclear protein in testis (NUT) carcinomas are very rare and have a very poor survival rate. The most common sites of involvement include the nasal cavity, sinus, and mediastinum. Laryngeal NUT midline carcinoma is extremely rare, with only 2 cases reported thus far. Here, we are describing another case of NUT laryngeal carcinoma. Methods and Results: The patient was a light smoker and nondrinker who presented with upper respiratory tract obstruction. Imaging and laryngoscopic evaluation revealed a large intraluminal laryngeal mass. Biopsy demonstrated poorly differentiated carcinoma with intact mucosa and only focal coexpression of CK5/6 and p40. NUT protein immune-stain positivity conclusively established the diagnosis of NUT midline carcinoma. Conclusion: Absence of well-known risk factors, pathologic finding of lack of mucosal involvement and lack of squamous differentiation with poorly differentiated carcinoma, should prompt clinicians to consider this rare entity as a possible diagnosis.

Original languageEnglish (US)
Pages (from-to)E2471-E2474
JournalHead and Neck
Issue number8
StatePublished - Aug 1 2016
Externally publishedYes


  • laryngeal carcinoma
  • nuclear protein in testis (NUT) midline carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology


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