@article{90902db9c6f142ebbc3a6f92112e159d,
title = "{"}Nought May Endure but Mutability{"}: Spliceosome Dynamics and the Regulation of Splicing",
abstract = "The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.",
author = "Smith, {Duncan J.} and Query, {Charles C.} and Konarska, {Maria M.}",
note = "Funding Information: We offer our apologies to those whose work we could not cite directly due to space constraints. We thank Doug Black, Beth Moorefield, Erik Sontheimer, Jon Staley, and Juan Valcarcel for comments on the manuscript; numerous other colleagues for sharing prepublication data to which we cannot refer; and Allison Amend for introducing us to the poem from which the title is derived. Title quotation from “Mutability” (1816) by P.B. Shelley: full text available at http://www.litscape.com/author/Percy_Bysshe_Shelley/Mutability.html . This work was supported by NIH grant GM49044 to M.M.K. and by NIH grant GM57829 to C.C.Q.",
year = "2008",
month = jun,
day = "20",
doi = "10.1016/j.molcel.2008.04.013",
language = "English (US)",
volume = "30",
pages = "657--666",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "6",
}