"Nought May Endure but Mutability": Spliceosome Dynamics and the Regulation of Splicing

Duncan J. Smith, Charles C. Query, Maria M. Konarska

Research output: Contribution to journalReview articlepeer-review

127 Scopus citations


The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.

Original languageEnglish (US)
Pages (from-to)657-666
Number of pages10
JournalMolecular Cell
Issue number6
StatePublished - Jun 20 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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