Non-pulmonary vein triggers in nonparoxysmal atrial fibrillation: Implications of pathophysiology for catheter ablation

Domenico G. Della Rocca, Nicola Tarantino, Chintan Trivedi, Sanghamitra Mohanty, Alisara Anannab, Anu S. Salwan, Carola Gianni, Mohamed Bassiouny, Amin Al-Ahmad, Jorge Romero, David F. Briceño, J. David Burkhardt, G. Joseph Gallinghouse, Rodney P. Horton, Luigi Di Biase, Andrea Natale

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Rhythm control of persistent atrial fibrillation (AF) patients represents a challenge for the modern interventional cardiac electrophysiologist; as a matter of fact, there is still divergence regarding the best ablative approach to adopt in this population. Different investigational endpoints, variability of techniques and tools, significant technological evolution, and the lack of universally accepted pathophysiological models engendered a considerable heterogeneity in terms of techniques and outcomes, so much that the treatment of persistent subtypes of AF commonly still relies mainly on pulmonary vein (PV) isolation. The purpose of the present review is to report the current experimental and clinical evidence supporting the importance of mapping and ablating non-PV triggers and describe our institutional approach for the ablation of nonparoxysmal AF.

Original languageEnglish (US)
Pages (from-to)2154-2167
Number of pages14
JournalJournal of cardiovascular electrophysiology
Issue number8
StatePublished - Aug 1 2020


  • atrial fibrillation
  • catheter ablation
  • coronary sinus
  • crista terminalis
  • interatrial septum
  • left atrial appendage
  • mapping
  • outcomes
  • pathophysiology
  • pulmonary vein
  • superior vena cava
  • trigger

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'Non-pulmonary vein triggers in nonparoxysmal atrial fibrillation: Implications of pathophysiology for catheter ablation'. Together they form a unique fingerprint.

Cite this