TY - JOUR
T1 - Non-coding RNA networks underlying cognitive disorders across the lifespan
AU - Qureshi, Irfan A.
AU - Mehler, Mark F.
N1 - Funding Information:
We regret that space constraints have prevented the citation of many relevant and important references. M.F.M. is supported by grants from the National Institutes of Health (NS38902, MH66290, NS071571), as well as by the Roslyn and Leslie Goldstein, Harold and Isabel Feld, Mildred and Bernard H. Kayden, F.M. Kirby and Alpern Family Foundations.
PY - 2011/6
Y1 - 2011/6
N2 - Non-coding RNAs (ncRNAs) and their associated regulatory networks are increasingly being implicated in mediating a complex repertoire of neurobiological functions. Cognitive and behavioral processes are proving to be no exception. In this review, we discuss the emergence of many novel, diverse and rapidly expanding classes and subclasses of short and long ncRNAs. We briefly review the life cycles and molecular functions of these ncRNAs. We also examine how ncRNA circuitry mediates brain development, plasticity, stress responses and aging, and highlight its potential roles in the pathophysiology of cognitive disorders, including neural developmental and age-associated neurodegenerative diseases, as well as those that manifest throughout the lifespan.
AB - Non-coding RNAs (ncRNAs) and their associated regulatory networks are increasingly being implicated in mediating a complex repertoire of neurobiological functions. Cognitive and behavioral processes are proving to be no exception. In this review, we discuss the emergence of many novel, diverse and rapidly expanding classes and subclasses of short and long ncRNAs. We briefly review the life cycles and molecular functions of these ncRNAs. We also examine how ncRNA circuitry mediates brain development, plasticity, stress responses and aging, and highlight its potential roles in the pathophysiology of cognitive disorders, including neural developmental and age-associated neurodegenerative diseases, as well as those that manifest throughout the lifespan.
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U2 - 10.1016/j.molmed.2011.02.002
DO - 10.1016/j.molmed.2011.02.002
M3 - Review article
C2 - 21411369
AN - SCOPUS:79958770713
SN - 1471-4914
VL - 17
SP - 337
EP - 346
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 6
ER -