TY - JOUR
T1 - No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study
AU - Duan, Shiwei
AU - Yin, Hua
AU - Chen, Wuyan
AU - Xing, Qinhe
AU - Chen, Qi
AU - Guo, Tingwei
AU - Gao, Jianjun
AU - Li, Xiuxia
AU - Gao, Rui
AU - Liu, Zhuangjun
AU - Gu, Niufan
AU - Feng, Guoyin
AU - He, Lin
N1 - Funding Information:
We would sincerely thank all the subjects for their participation in this study and all the medical staff involved in specimen collecting. This work was supported by grants from the National 863 and 973 Programs, National Natural Science Foundation of China, Municipal Commission of Science and Technology Shanghai, and the Ministry of Education.
PY - 2005/3/11
Y1 - 2005/3/11
N2 - Previous studies have demonstrated that polymorphisms in the putative promoter region of the human serotonin receptor 1B (HTR1B) gene affect gene expression [H.F. Sun, Y.T. Chang, C.S. Fann, C.J. Chang, Y.H. Chen, Y.P. Hsu, W.Y. Yu, A.T. Cheng, Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han, Biol. Psychiatry 51 (2002) 896-901; J. Duan, A.R. Sanders, J.E. Molen, L. Martinolich, B.J. Mowry, D.F. Levinson, R.R. Crowe, J.M. Silverman, P.V. Gejman, Polymorphisms in the 5′-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression, Mol. Psychiatry 8 (2003) 901-910]. And the silent mutation G861C allele has been reported to be associated with several psychiatric disorders. Thus, we performed a case-control association study (456 cases and 557 controls) of the five variants in HTR1B gene (T-261G, -182INS/DEL-181, A-161T, C129T and G861C) with schizophrenia. The results showed that neither the allelic distribution nor the major haplotype distribution (except for a rare haplotype) of five SNPs in patients was significantly different from that in controls. A further family-based association study (229 family trios) of G861C allele suggested that HTR1B was not a susceptible gene with schizophrenia in our sample. In conclusion, these data do not support the idea that HTR1B gene plays a major role in the etiopathogenesis of schizophrenia in Chinese Han population.
AB - Previous studies have demonstrated that polymorphisms in the putative promoter region of the human serotonin receptor 1B (HTR1B) gene affect gene expression [H.F. Sun, Y.T. Chang, C.S. Fann, C.J. Chang, Y.H. Chen, Y.P. Hsu, W.Y. Yu, A.T. Cheng, Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han, Biol. Psychiatry 51 (2002) 896-901; J. Duan, A.R. Sanders, J.E. Molen, L. Martinolich, B.J. Mowry, D.F. Levinson, R.R. Crowe, J.M. Silverman, P.V. Gejman, Polymorphisms in the 5′-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression, Mol. Psychiatry 8 (2003) 901-910]. And the silent mutation G861C allele has been reported to be associated with several psychiatric disorders. Thus, we performed a case-control association study (456 cases and 557 controls) of the five variants in HTR1B gene (T-261G, -182INS/DEL-181, A-161T, C129T and G861C) with schizophrenia. The results showed that neither the allelic distribution nor the major haplotype distribution (except for a rare haplotype) of five SNPs in patients was significantly different from that in controls. A further family-based association study (229 family trios) of G861C allele suggested that HTR1B was not a susceptible gene with schizophrenia in our sample. In conclusion, these data do not support the idea that HTR1B gene plays a major role in the etiopathogenesis of schizophrenia in Chinese Han population.
KW - Association study
KW - HTR1B
KW - Polymorphisms
KW - Schizophrenia
KW - Serotonin receptor
KW - TDT
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U2 - 10.1016/j.neulet.2004.11.028
DO - 10.1016/j.neulet.2004.11.028
M3 - Article
C2 - 15698927
AN - SCOPUS:13444269377
SN - 0304-3940
VL - 376
SP - 93
EP - 97
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -