Nipping at cardiac remodeling

Russell S. Whelan; Kartik Mani; Richard N. Kitsis

doi:10.1172/JCI33706

Nipping at cardiac remodeling

Russell S. Whelan, Kartik Mani, Richard N. Kitsis

Medicine

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size (see the related article beginning on page 2825).

Original language	English (US)
Pages (from-to)	2751-2753
Number of pages	3
Journal	Journal of Clinical Investigation
Volume	117
Issue number	10
DOIs	https://doi.org/10.1172/JCI33706
State	Published - Oct 1 2007

ASJC Scopus subject areas

General Medicine

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10.1172/JCI33706

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title = "Nipping at cardiac remodeling",

abstract = "Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size (see the related article beginning on page 2825).",

author = "Whelan, {Russell S.} and Kartik Mani and Kitsis, {Richard N.}",

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AU - Whelan, Russell S.

AU - Mani, Kartik

AU - Kitsis, Richard N.

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N2 - Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size (see the related article beginning on page 2825).

AB - Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size (see the related article beginning on page 2825).

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Nipping at cardiac remodeling

Abstract

ASJC Scopus subject areas

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