Nipping at cardiac remodeling

Russell S. Whelan, Kartik Mani, Richard N. Kitsis

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size (see the related article beginning on page 2825).

Original languageEnglish (US)
Pages (from-to)2751-2753
Number of pages3
JournalJournal of Clinical Investigation
Issue number10
StatePublished - Oct 1 2007

ASJC Scopus subject areas

  • General Medicine


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