TY - JOUR
T1 - NFAT proteins
T2 - Key regulators of T-cell development and function
AU - Macian, Fernando
N1 - Funding Information:
I thank A. M. Cuervo for critical reading of this manuscript. I give special thanks to A. Rao for stimulating discussions and many useful suggestions. I apologize to those colleagues whose work I could not cite owing to space limitations. This work was supported by grants from the National Institutes of Health (United States) and the Irene Diamond Fund (United States).
PY - 2005/6
Y1 - 2005/6
N2 - Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of transcription factors has grown to include five members. It has also become clear that NFAT proteins have crucial roles in the development and function of the immune system. In T cells, NFAT proteins not only regulate activation but also are involved in the control of thymocyte development, T-cell differentiation and self-tolerance, The functional versatility of NFAT proteins can be explained by their complex mechanism of regulation and their ability to integrate calcium signalling with other signalling pathways. This Review focuses on the recent advances in our understanding of the regulation, mechanism of action and functions of NFAT proteins in T cells.
AB - Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of transcription factors has grown to include five members. It has also become clear that NFAT proteins have crucial roles in the development and function of the immune system. In T cells, NFAT proteins not only regulate activation but also are involved in the control of thymocyte development, T-cell differentiation and self-tolerance, The functional versatility of NFAT proteins can be explained by their complex mechanism of regulation and their ability to integrate calcium signalling with other signalling pathways. This Review focuses on the recent advances in our understanding of the regulation, mechanism of action and functions of NFAT proteins in T cells.
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U2 - 10.1038/nri1632
DO - 10.1038/nri1632
M3 - Review article
C2 - 15928679
AN - SCOPUS:20644466433
SN - 1474-1733
VL - 5
SP - 472
EP - 484
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 6
ER -