Abstract
It has recently been established that bone marrow-derived endothelial progenitor cells (EPCs) are recruited to the systemic circulation and, in response to various cytokines, pharmacologic agents, and/or tissue ischemia, incorporate into sites of new blood vessel growth (neovascularization). These findings have changed our understanding of adult neovascularization by demonstrating that both preexisting endothelial cells and EPCs contribute to blood vessel formation during adult life. The following review article highlights the discovery of EPCs, their relationship to various clinical diseases, and their therapeutic potential for augmenting blood vessel formation.
Original language | English (US) |
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Pages (from-to) | 353-359 |
Number of pages | 7 |
Journal | Journal of Investigative Medicine |
Volume | 51 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2003 |
Externally published | Yes |
Keywords
- Angiogenesis
- Cell/gene therapy
- Endothelial progenitor cells
- Therapeutic vasculogenesis
- Vasculogenesis
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology