Abstract
BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.
Original language | English (US) |
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Pages (from-to) | 456-460 |
Number of pages | 5 |
Journal | Nature |
Volume | 351 |
Issue number | 6326 |
DOIs | |
State | Published - 1991 |
ASJC Scopus subject areas
- General