New treatments for hepatitis C: Life cycle lessons

Ilan S. Weisberg, Samuel H. Sigal, Ira M. Jacobson

Research output: Contribution to journalReview articlepeer-review


Despite progressive advances, therapy with interferon and ribavirin has been the mainstay of treatment for chronic hepatitis C for over a decade. With the development of in vitro systems to study viral replication, there have been great advances in the understanding of hepatitis C biology, and these advances, in turn, are allowing the development of specifically targeted antiviral therapies. This review employs our current understanding of the hepatitis C replicative life cycle as a framework on which to discuss new antiviral agents under clinical investigation.

Original languageEnglish (US)
Pages (from-to)75-82
Number of pages8
JournalCurrent Hepatitis Reports
Issue number2
StatePublished - May 2007
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Virology


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