TY - JOUR
T1 - New medicinal properties of mangostins
T2 - Analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L.
AU - Cui, Jihong
AU - Hu, Wen
AU - Cai, Zhanjun
AU - Liu, Yingxue
AU - Li, Siyuan
AU - Tao, Wucheng
AU - Xiang, Hui
N1 - Funding Information:
This work was supported by grants from Guangdong Science-Tech Program (No. 2001331004202516 ) and the Science Foundation of the Sun Yat-sen University Life Sciences School .
PY - 2010/4
Y1 - 2010/4
N2 - The fruit hull of Garcinia mangostana L. contains oxygenated and prenylated phenol derivatives, such as xanthones or xanthen-9H-ones, and is used by people in Southeast Asia as a traditional medicine for the treatment of abdominal pain, dysentery, wound infections, suppuration, and chronic ulcer. We isolated the active ingredients from the crude ethanol extract of G. mangostana L. (CEM) and investigated their analgesic effects and underlying mechanisms. CEM at intragastric (i.g.) doses of 0.5, 1, and 3 g/kg clearly exhibited antinociceptive effects in the hot-plate and acetic acid-induced writhing tests in mice. Two isolated compounds, α-mangostin and γ-mangostin, exhibited analgesic effects at doses of 25 and 50 mg/kg (i.g.) in the hot-plate and formalin tests, respectively. CEM at doses of 0.5, 1, and 3 g/kg significantly inhibited xylene-induced release of inflammatory mediators. CEM, α-mangostin, and γ-mangostin each dose-dependently demonstrated the ability to scavenge reactive oxygen species. In conclusion, our results demonstrate that CEM and mangostins possess potent peripheral and central antinociceptive effects in mice and suggest that xanthones may be developed as novel analgesics and anti-inflammatory drugs.
AB - The fruit hull of Garcinia mangostana L. contains oxygenated and prenylated phenol derivatives, such as xanthones or xanthen-9H-ones, and is used by people in Southeast Asia as a traditional medicine for the treatment of abdominal pain, dysentery, wound infections, suppuration, and chronic ulcer. We isolated the active ingredients from the crude ethanol extract of G. mangostana L. (CEM) and investigated their analgesic effects and underlying mechanisms. CEM at intragastric (i.g.) doses of 0.5, 1, and 3 g/kg clearly exhibited antinociceptive effects in the hot-plate and acetic acid-induced writhing tests in mice. Two isolated compounds, α-mangostin and γ-mangostin, exhibited analgesic effects at doses of 25 and 50 mg/kg (i.g.) in the hot-plate and formalin tests, respectively. CEM at doses of 0.5, 1, and 3 g/kg significantly inhibited xylene-induced release of inflammatory mediators. CEM, α-mangostin, and γ-mangostin each dose-dependently demonstrated the ability to scavenge reactive oxygen species. In conclusion, our results demonstrate that CEM and mangostins possess potent peripheral and central antinociceptive effects in mice and suggest that xanthones may be developed as novel analgesics and anti-inflammatory drugs.
KW - Acetic acid-induced writhing test
KW - Analgesic effect
KW - Anti-inflammatory activity
KW - Antioxidation
KW - Formalin test
KW - Garcinia mangostana L.
KW - Hot-plate test
KW - Hydroxyl radicals
KW - Superoxide radical
KW - α-mangostin
KW - γ-mangostin
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U2 - 10.1016/j.pbb.2009.12.021
DO - 10.1016/j.pbb.2009.12.021
M3 - Article
C2 - 20064550
AN - SCOPUS:76949102296
SN - 0091-3057
VL - 95
SP - 166
EP - 172
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 2
ER -