Neuromuscular blockers

Gabriel Goodwin; Vilma Joseph

doi:10.1007/978-1-4614-8948-1_12

Neuromuscular blockers

Gabriel Goodwin, Vilma Joseph

Anesthesiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Muscle relaxants were first used on poisonous darts by South American Indians during hunting, according to accounts found in the court of King Ferdinand and Queen Isabella. It took several hundred years until their therapeutic potential was realized in the medical setting. Tubocurarine, the first muscle relaxant used clinically, often produced hypotension and tachycardia through histamine release. Today, we have sophisticated neuromuscular blockers (NMBs) that keep the patient paralyzed providing ideal surgical conditions, facilitating intubation and artificial ventilation, with minimal changes to vital signs.

Original language	English (US)
Title of host publication	Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care
Publisher	Springer New York
Pages	195-204
Number of pages	10
ISBN (Electronic)	9781461489481
ISBN (Print)	9781461489474
DOIs	https://doi.org/10.1007/978-1-4614-8948-1_12
State	Published - Jan 1 2015

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-4614-8948-1_12

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AB - Muscle relaxants were first used on poisonous darts by South American Indians during hunting, according to accounts found in the court of King Ferdinand and Queen Isabella. It took several hundred years until their therapeutic potential was realized in the medical setting. Tubocurarine, the first muscle relaxant used clinically, often produced hypotension and tachycardia through histamine release. Today, we have sophisticated neuromuscular blockers (NMBs) that keep the patient paralyzed providing ideal surgical conditions, facilitating intubation and artificial ventilation, with minimal changes to vital signs.

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BT - Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care

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ER -

Neuromuscular blockers

Abstract

ASJC Scopus subject areas

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