Neurological complications in infants and children with acquired immune deficiency syndrome

Anita Lesgold Belman, Monica H. Ultmann, Dikran Horoupian, Brian Novick, Alfred J. Spiro, Arye Rubinstein, Diane Kurtzberg, Barbara Cone‐Wesson

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218 Scopus citations


Neurological complications occurred in 6 children, aged 6 months to 5 years, with acquired immune deficiency syndrome who were followed for 14 months. The most frequent manifestations included encephalopathies, acquired microcephaly, and pyramidal tract signs. Computed tomographic examinations showed variable degrees of cortical atrophy with ventricular dilatation and calcification. Electrophysiological abnormalities were demonstrated. Two children had documented central nervous system infections. Neurological deterioration resulted in dementia in 3 children. Cognitive impairment and developmental delays were evident in the other 3. Postmortem examination of the 3 children who died showed subacute cytomegalovirus encephalitis in 1; nonspecific hemispheric white matter changes, calcific vasopathy of the basal ganglia, and striking bilateral corticospinal tract degeneration in the second; and extensive calcific vasopathy of the basal ganglia and frontal centrum semiovale, and bilateral attenuation of the frontopontine and corticospinal tracts in the third.

Original languageEnglish (US)
Pages (from-to)560-566
Number of pages7
JournalAnnals of Neurology
Issue number5
StatePublished - Nov 1985

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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