Neuroimaging of Pediatric Arteriopathies

Pradeep Goyal, Ajay Malhotra, Jeevak Almast, Joshua Sapire, Sonali Gupta, Manisha Mangla, Rajiv Mangla

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Pediatric arteriopathies are increasingly recognized in school-aged children with a variety of presenting symptoms ranging from headache, seizures, encephalopathy, and neuropsychiatric symptoms as well as focal neurologic deficits due to acute ischemic strokes. However, unlike the adult stroke population, there are differences in the clinical manifestations, the stroke mechanism, and risk factors in pediatric ischemic stroke. There has been increasing awareness and recognition of pediatric cerebral arteriopathies as a predominant stroke etiology. Prompt diagnosis of arteriopathies is essential to limit injury and prevent recurrent stroke. Based on predominant vessels involved and clinical symptoms, these arteriopathies can be broadly divided into two categories: large-medium size arteriopathies and small vessel arteriopathies. Each category can be further divided into inflammatory and noninflammatory according to their etiologies. The ability to distinguish between inflammatory and noninflammatory etiologies carries major prognostic implications for acute management and secondary stroke prevention as well as screening for systemic complications and counseling.

Original languageEnglish (US)
Pages (from-to)287-308
Number of pages22
JournalJournal of Neuroimaging
Issue number3
StatePublished - May 1 2019
Externally publishedYes


  • acute ischemic stroke
  • CASCADE criteria
  • focal cerebral arteriopathy
  • genetically determined arteriopathies
  • Moyamoya disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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