Neurofibrillary degeneration in a case of quadriplegia and myoclonic movement

S. Kuroda, S. Otsuki, J. Tateishi, A. Hirano

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A case of spastic quadriplegia with myoclonic movement was studied by both light and electron microscope. Argentophilic inclusions were found in a unique distribution involving the cerebral cortex, brain stem, cerebellum, and the spinal cord, including the motor neuron system. The fine structure of the inclusions consisted of accumulation of previously undescribed straight or wavy tubules approximately 120A wide devoid of periodic constriction.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalActa neuropathologica
Issue number2
StatePublished - Jan 1979


  • Anterior horn cell
  • Electron microscope
  • Neurofibrillary change
  • Neurofilaments

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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