Neurobehavioral and physiologic effects of trifluoromethane in humans

Susan C. Fagan, Alice A. Rahill, Guruswamy Balakrishnan, James R. Ewing, Craig A. Branch, Gregory G. Brown

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Nuclear magnetic resonance (NMR) imaging shows promise in the measurement of human cerebral blood flow (CBF) in that nonradioactive indicators may be used. Our earlier investigations with trifluoromethane (FC-23) gas have shown that this compound can be used to safely and effectively measure CBF in anesthetized animal models. In this Phase I dose-escalation study we set out to determine the maximal tolerated concentration (MTC) of FC-23 in normal healthy male volunteers and to assess its feasibility as an NMR indicator. Five subjects were exposed in a blinded fashion to escalating concentrations of FC-23 between 10% and 60%, randomly interleaved with exposures to both room air and 40% nitrous oxide. On each study day, the subjects breathed the test gas for eight pulses of 3 min each with 2-min.

Original languageEnglish (US)
Pages (from-to)221-229
Number of pages9
JournalJournal of Toxicology and Environmental Health
Issue number2
StatePublished - Jun 1995
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pollution


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