Networks: The Substantia Nigra in the Control of Seizures

M. H. Scantlebury, A. S. Galanopoulou, J. Velíšková, S. L. Moshé

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


The overall goal of research in many laboratories is to identify mechanisms involved in the suppression of seizures as a function of age and gender. Epidemiological studies suggest that early in life, the brain is very susceptible to seizures and especially status epilepticus (SE). The substantia nigra pars reticulata (SNR) is one of the brain sites critically involved in the control of seizures. Understanding the normal development of this endogenous system, as well as the spectrum and progressive nature of SE-induced changes in brain function, may have important implications in the design of treatments aimed at disease modification - particularly with respect to specific age groups in either gender.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Basic Epilepsy Research
PublisherElsevier Inc.
Number of pages9
ISBN (Print)9780123739612
StatePublished - Jan 1 2009


  • Autoradiography
  • Basal ganglia
  • Chloride cotransporter
  • Development
  • Epilepsy
  • Estrogen
  • GABA
  • GABA receptor
  • Glucose uptake
  • Inhibition
  • Muscimol
  • Seizure suppression
  • Status epilepticus (SE)
  • Substantia nigra
  • Substantia nigra pars reticulate
  • Testosterone

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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