NEO-FFI factor scores as predictors of clinical response to fluoxetine in depressed outpatients

Timothy Petersen, George I. Papakostas, Kathryn Bottonari, Brian Iacoviello, Jonathan E. Alpert, Maurizio Fava, Andrew A. Nierenberg

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Research in unipolar depression suggests that neuroticism is associated with poor long-term outcome and greater chronicity. The objective of this study was to determine whether baseline neuroticism scores predict response to treatment with fluoxetine in depressed outpatients. Seventy-six depressed outpatients participating in a clinical trial of fluoxetine (fixed/flexible dosing) completed the NEO-FFI (five factor inventory short form) at baseline. Clinical response was defined as a 50% or greater decrease in the 17-item Hamilton Depression Rating Scale (HAM-D-17) total score (final visit - baseline). Logistic regression evaluated NEO-FFI factor scores as predictors of treatment outcome within an intent-to-treat model. Scores on the neuroticism scale were not found to significantly predict treatment response as measured by the HAM-D-17. Strengths of this study include a standardized treatment protocol and use of structured interview instruments, while limitations include a modest sample size, lack of continuation data, state/trait effects, and lack of generalizability to other antidepressant treatments.

Original languageEnglish (US)
Pages (from-to)9-16
Number of pages8
JournalPsychiatry Research
Issue number1
StatePublished - Jan 31 2002
Externally publishedYes


  • Depression
  • Neuroticism
  • Personality
  • Response to treatment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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