TY - JOUR
T1 - Navigating and diagnosing cognitive frailty in research and clinical domains
AU - Nader, Monica M.
AU - Cosarderelioglu, Caglar
AU - Miao, Emily
AU - Whitson, Heather
AU - Xue, Qian Li
AU - Grodstein, Francine
AU - Oh, Esther
AU - Ferrucci, Luigi
AU - Bennett, David A.
AU - Walston, Jeremy D.
AU - George, Claudene
AU - Abadir, Peter M.
N1 - Publisher Copyright:
© 2023, Springer Nature America, Inc.
PY - 2023/11
Y1 - 2023/11
N2 - While physical frailty has been recognized as a clinical entity for some time, the concept of cognitive frailty (CF) is now gaining increasing attention in the geriatrics research community. CF refers to the co-occurrence of physical frailty and cognitive impairment in older adults, which has been suggested as a potential precursor to both dementia and adverse physical outcomes. However, this condition represents a challenge for researchers and clinicians, as there remains a lack of consensus regarding the definition and diagnostic criteria for CF, which has limited its utility. Here, using insights from both the physical frailty literature and cognitive science research, we describe emerging research on CF. We highlight areas of agreement as well as areas of confusion and remaining knowledge gaps, and provide our perspective on fine-tuning the current construct, aiming to stimulate further discussion in this developing field.
AB - While physical frailty has been recognized as a clinical entity for some time, the concept of cognitive frailty (CF) is now gaining increasing attention in the geriatrics research community. CF refers to the co-occurrence of physical frailty and cognitive impairment in older adults, which has been suggested as a potential precursor to both dementia and adverse physical outcomes. However, this condition represents a challenge for researchers and clinicians, as there remains a lack of consensus regarding the definition and diagnostic criteria for CF, which has limited its utility. Here, using insights from both the physical frailty literature and cognitive science research, we describe emerging research on CF. We highlight areas of agreement as well as areas of confusion and remaining knowledge gaps, and provide our perspective on fine-tuning the current construct, aiming to stimulate further discussion in this developing field.
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U2 - 10.1038/s43587-023-00504-z
DO - 10.1038/s43587-023-00504-z
M3 - Article
AN - SCOPUS:85174272084
SN - 2662-8465
VL - 3
SP - 1325
EP - 1333
JO - Nature Aging
JF - Nature Aging
IS - 11
ER -