Natalizumab-induced hepatic injury: A case report and review of literature

A. Antezana, S. Sigal, J. Herbert, I. Kister

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Natalizumab is an α4-integrin monoclonal antibody used for treatment of relapsing multiple sclerosis (MS). At least and nearly 30 cases of liver failure in natalizumab-treated patients are listed in the post-marketing FDA adverse event reporting system (FAERS) and twelve patients with severe liver injury, including several after the first infusion, have been reported (Lisotti et al., 2012; Bezabeh et al., 2010; Martinez-Lapiscina et al., 2013; Michael et al., 2007; Hillen et al., 2015). Herein, we describe a case of a young woman with relapsing MS who developed acute liver injury after the second infusion of natalizumab. Liver biopsy demonstrated a mixed pattern of medication-induced injury or partially treated auto-immune hepatitis. Liver function normalized after natalizumab discontinuation and a subsequent liver biopsy showed resolution of hepatitis. The patient's MS has since been successfully treated with rituximab for over a year. We review the published cases of liver injury associated with natalizumab and those in the post-marketing FDA adverse event reporting system (FAERS).

Original languageEnglish (US)
Pages (from-to)495-498
Number of pages4
JournalMultiple Sclerosis and Related Disorders
Issue number6
StatePublished - Nov 2015
Externally publishedYes


  • Autoimmune hepatitis
  • Drug-induced liver injury
  • Hepatotoxicity
  • Natalizumab

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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