Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase

Wei Zhao; Bing Xiong Fang; Yu Jie Niu; Yi Na Liu; Bin Liu; Qi Peng; Jiang Bin Li; Brian M. Wasko; Joseph R. Delaney; Brian K. Kennedy; Yousin Suh; Zhong Jun Zhou; Matt Kaeberlein; Xin Guang Liu

doi:10.1016/j.mad.2014.01.007

Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase

Wei Zhao, Bing Xiong Fang, Yu Jie Niu, Yi Na Liu, Bin Liu, Qi Peng, Jiang Bin Li, Brian M. Wasko, Joseph R. Delaney, Brian K. Kennedy, Yousin Suh, Zhong Jun Zhou, Matt Kaeberlein, Xin Guang Liu

Genetics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Saccharomyces cerevisiae Nar1p is an essential Fe/S protein that exhibits striking similarity to bacterial iron-only hydrogenases. Nar1p is required for the maturation of cytosolic and nuclear, but not of mitochondrial Fe/S proteins, and plays a role in modulating sensitivity to oxygen in both yeast and Caenorhabditis elegans through unknown mechanisms. Here we report that Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. These data suggest that Nar1p promotes protection against oxidative stress and define a new role for Nar1p in promoting replicative lifespan.

Original language	English (US)
Pages (from-to)	53-58
Number of pages	6
Journal	Mechanisms of Ageing and Development
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/j.mad.2014.01.007
State	Published - Jun 2014

Keywords

Lifespan
Mitochondrial superoxide dismutase
Nar1

ASJC Scopus subject areas

Aging
Developmental Biology

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10.1016/j.mad.2014.01.007

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Zhao, W., Fang, B. X., Niu, Y. J., Liu, Y. N., Liu, B., Peng, Q., Li, J. B., Wasko, B. M., Delaney, J. R., Kennedy, B. K., Suh, Y., Zhou, Z. J., Kaeberlein, M., & Liu, X. G. (2014). Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. Mechanisms of Ageing and Development, 138(1), 53-58. https://doi.org/10.1016/j.mad.2014.01.007

Zhao, W, Fang, BX, Niu, YJ, Liu, YN, Liu, B, Peng, Q, Li, JB, Wasko, BM, Delaney, JR, Kennedy, BK, Suh, Y, Zhou, ZJ, Kaeberlein, M & Liu, XG 2014, 'Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase', Mechanisms of Ageing and Development, vol. 138, no. 1, pp. 53-58. https://doi.org/10.1016/j.mad.2014.01.007

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title = "Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase",

abstract = "Saccharomyces cerevisiae Nar1p is an essential Fe/S protein that exhibits striking similarity to bacterial iron-only hydrogenases. Nar1p is required for the maturation of cytosolic and nuclear, but not of mitochondrial Fe/S proteins, and plays a role in modulating sensitivity to oxygen in both yeast and Caenorhabditis elegans through unknown mechanisms. Here we report that Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. These data suggest that Nar1p promotes protection against oxidative stress and define a new role for Nar1p in promoting replicative lifespan.",

keywords = "Lifespan, Mitochondrial superoxide dismutase, Nar1",

author = "Wei Zhao and Fang, {Bing Xiong} and Niu, {Yu Jie} and Liu, {Yi Na} and Bin Liu and Qi Peng and Li, {Jiang Bin} and Wasko, {Brian M.} and Delaney, {Joseph R.} and Kennedy, {Brian K.} and Yousin Suh and Zhou, {Zhong Jun} and Matt Kaeberlein and Liu, {Xin Guang}",

note = "Funding Information: This work was supported by National Natural Science Foundation of China ( 30871440 , 31101051 , 81170327 ), Natural Science Foundation of Guangdong Province ( 9252402301000002 ), the Technology Planning Project for University Research Institutions and Medical and Health Organizations of Dongguan City ( 2012108102022 ), the Science & Technology Innovation Fund of Guangdong Medical College ( STIF201102 ) and the Ph.D. Start-up Fund of Guangdong Medical College ( B2012061 ). JRD was supported by NIH Training Grant T32AG000057 . BMW was supported by NIH Training Grant T32ES007032 . We are grateful to Brett Robison, Mark McCormick, and Chong He for technical assistance and for supplying yeast strains and plasmids.",

year = "2014",

month = jun,

doi = "10.1016/j.mad.2014.01.007",

language = "English (US)",

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pages = "53--58",

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T1 - Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase

AU - Zhao, Wei

AU - Fang, Bing Xiong

AU - Niu, Yu Jie

AU - Liu, Yi Na

AU - Liu, Bin

AU - Peng, Qi

AU - Li, Jiang Bin

AU - Wasko, Brian M.

AU - Delaney, Joseph R.

AU - Kennedy, Brian K.

AU - Suh, Yousin

AU - Zhou, Zhong Jun

AU - Kaeberlein, Matt

AU - Liu, Xin Guang

N1 - Funding Information: This work was supported by National Natural Science Foundation of China ( 30871440 , 31101051 , 81170327 ), Natural Science Foundation of Guangdong Province ( 9252402301000002 ), the Technology Planning Project for University Research Institutions and Medical and Health Organizations of Dongguan City ( 2012108102022 ), the Science & Technology Innovation Fund of Guangdong Medical College ( STIF201102 ) and the Ph.D. Start-up Fund of Guangdong Medical College ( B2012061 ). JRD was supported by NIH Training Grant T32AG000057 . BMW was supported by NIH Training Grant T32ES007032 . We are grateful to Brett Robison, Mark McCormick, and Chong He for technical assistance and for supplying yeast strains and plasmids.

PY - 2014/6

Y1 - 2014/6

N2 - Saccharomyces cerevisiae Nar1p is an essential Fe/S protein that exhibits striking similarity to bacterial iron-only hydrogenases. Nar1p is required for the maturation of cytosolic and nuclear, but not of mitochondrial Fe/S proteins, and plays a role in modulating sensitivity to oxygen in both yeast and Caenorhabditis elegans through unknown mechanisms. Here we report that Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. These data suggest that Nar1p promotes protection against oxidative stress and define a new role for Nar1p in promoting replicative lifespan.

AB - Saccharomyces cerevisiae Nar1p is an essential Fe/S protein that exhibits striking similarity to bacterial iron-only hydrogenases. Nar1p is required for the maturation of cytosolic and nuclear, but not of mitochondrial Fe/S proteins, and plays a role in modulating sensitivity to oxygen in both yeast and Caenorhabditis elegans through unknown mechanisms. Here we report that Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. These data suggest that Nar1p promotes protection against oxidative stress and define a new role for Nar1p in promoting replicative lifespan.

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KW - Mitochondrial superoxide dismutase

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Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase

Abstract

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