Nanoparticles mediated tumor microenvironment modulation: current advances and applications

Ganji Seeta Rama Raju, Eluri Pavitra, Ganji Lakshmi Varaprasad, Sai Samyuktha Bandaru, Ganji Purnachandra Nagaraju, Batoul Farran, Yun Suk Huh, Young Kyu Han

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


The tumor microenvironment (TME) plays a key role in cancer development and emergence of drug resistance. TME modulation has recently garnered attention as a potential approach for reprogramming the TME and resensitizing resistant neoplastic niches to existing cancer therapies such as immunotherapy or chemotherapy. Nano-based solutions have important advantages over traditional platform and can be specifically targeted and delivered to desired sites. This review explores novel nano-based approaches aimed at targeting and reprogramming aberrant TME components such as macrophages, fibroblasts, tumor vasculature, hypoxia and ROS pathways. We also discuss how nanoplatforms can be combined with existing anti-tumor regimens such as radiotherapy, immunotherapy, phototherapy or chemotherapy to enhance clinical outcomes in solid tumors.

Original languageEnglish (US)
Article number274
JournalJournal of Nanobiotechnology
Issue number1
StatePublished - Dec 2022
Externally publishedYes


  • Chemotherapy
  • Drug delivery
  • Immunotherapy
  • Nanoparticles
  • Photodynamic therapy
  • Tumor microenvironment

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Applied Microbiology and Biotechnology
  • Pharmaceutical Science


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