Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer

Nicholas E. Baker; Abhijit Kale

doi:10.1080/23723556.2015.1029065

Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer

Nicholas E. Baker, Abhijit Kale

Genetics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.

Original language	English (US)
Article number	e1029065
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1029065
State	Published - Jan 2 2016

Keywords

Drosophila melanogaster
apoptosis
cancer predisposition
genetic mosaic
ribosomal protein
somatic mutation

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2015.1029065

Cite this

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abstract = "Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.",

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AU - Kale, Abhijit

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AB - Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.

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KW - cancer predisposition

KW - genetic mosaic

KW - ribosomal protein

KW - somatic mutation

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Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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