TY - JOUR
T1 - Multisensory Integration Predicts Balance and Falls in Older Adults
AU - Mahoney, Jeannette R.
AU - Cotton, Kelly
AU - Verghese, Joe
AU - Newman, Anne
N1 - Publisher Copyright:
© 2018 The Author(s). Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
PY - 2019/8/16
Y1 - 2019/8/16
N2 - Background: Effective integration of concurrent sensory information is crucial for successful locomotion. This study aimed to determine the association of multisensory integration with mobility outcomes in aging. Methods: A total of 289 healthy older adults (mean age 76.67 ± 6.37 years; 53% female participants) participated in a visual-somatosensory simple reaction time task. Magnitude of multisensory effects was assessed using probability models, and then categorized into four multisensory integration classifications (superior, good, poor, or deficient). Associations of multisensory integration with falls and balance (unipedal stance) were tested at cross-section and longitudinally using Cox proportional hazards models. Results: At baseline, the prevalence of falls in the previous year was 24%, and 52% reported an incident fall over a mean follow-up period of 24 ± 17 months. Mean unipedal stance time was 15 ± 11 seconds. Magnitude of multisensory integration was a strong predictor of balance performance at cross-section (β = 0.11; p <. 05). Of the cohort, 31% had superior, 26% had good, 28% had poor, and 15% had deficient multisensory effects. Older adults with superior multisensory integration abilities were significantly less likely to report a fall in the past year (17%), compared to the rest of the cohort (28%; χ2 = 4.01; p =. 04). Magnitude of multisensory integration was an incremental predictor of incident falls (adjusted hazard ratio = 0.24; p =. 01), over and above balance and other known fall risk factors. Conclusions: Our study highlights the clinical relevance of multisensory integration in aging; worse visual-somatosensory integration is associated with worse balance and increased risk of incident falls.
AB - Background: Effective integration of concurrent sensory information is crucial for successful locomotion. This study aimed to determine the association of multisensory integration with mobility outcomes in aging. Methods: A total of 289 healthy older adults (mean age 76.67 ± 6.37 years; 53% female participants) participated in a visual-somatosensory simple reaction time task. Magnitude of multisensory effects was assessed using probability models, and then categorized into four multisensory integration classifications (superior, good, poor, or deficient). Associations of multisensory integration with falls and balance (unipedal stance) were tested at cross-section and longitudinally using Cox proportional hazards models. Results: At baseline, the prevalence of falls in the previous year was 24%, and 52% reported an incident fall over a mean follow-up period of 24 ± 17 months. Mean unipedal stance time was 15 ± 11 seconds. Magnitude of multisensory integration was a strong predictor of balance performance at cross-section (β = 0.11; p <. 05). Of the cohort, 31% had superior, 26% had good, 28% had poor, and 15% had deficient multisensory effects. Older adults with superior multisensory integration abilities were significantly less likely to report a fall in the past year (17%), compared to the rest of the cohort (28%; χ2 = 4.01; p =. 04). Magnitude of multisensory integration was an incremental predictor of incident falls (adjusted hazard ratio = 0.24; p =. 01), over and above balance and other known fall risk factors. Conclusions: Our study highlights the clinical relevance of multisensory integration in aging; worse visual-somatosensory integration is associated with worse balance and increased risk of incident falls.
KW - Balance
KW - Brain aging
KW - Falls
KW - Multisensory integration
KW - Sensory
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U2 - 10.1093/gerona/gly245
DO - 10.1093/gerona/gly245
M3 - Article
C2 - 30357320
AN - SCOPUS:85072058530
SN - 1079-5006
VL - 74
SP - 1429
EP - 1435
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 9
ER -