Multicomponent Machines in RNA Modification: H/ACA Ribonucleoproteins

Petar Grozdanov, U. Thomas Meier

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Pseudouridylation, the isomerization of uridine to pseudouridine, is the most frequent posttranscriptional modification of RNA, such that pseudouridine has even been termed the fifth nucleotide. Whereas eubacteria employ single protein enzymes to identify and modify target uridines, archaebacteria and eukaryotes additionally evolved more complex modification machines, H/ACA ribonucleoproteins (RNPs). Each H/ACA RNP consists of a short RNA and the same four core proteins, one of which is the pseudouridine synthase related to the bacterial single protein enzymes. In this chapter, we will give an overview of these multicomponent machines with emphasis on the eukaryal systems that have acquired additional functions and that are the subject of the inherited bone marrow failure syndrome dyskeratosis congenita.

Original languageEnglish (US)
Title of host publicationDNA and RNA Modification Enzymes
Subtitle of host publicationStructure, Mechanism, Function and Evolution
PublisherCRC Press
Number of pages11
ISBN (Electronic)9781498713153
ISBN (Print)9781587063299
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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