Multi-vendor multi-site T and T2 quantification of knee cartilage

J. Kim, K. Mamoto, R. Lartey, K. Xu, K. Nakamura, W. Shin, C. S. Winalski, N. Obuchowski, M. Tanaka, E. Bahroos, T. M. Link, P. A. Hardy, Q. Peng, R. Reddy, A. Botto-van Bemden, K. Liu, R. D. Peters, C. Wu, X. Li

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Objective: To develop 3D T and T2 imaging based on the same sequence structure on MR systems from multiple vendors, and to evaluate intra-site repeatability and inter-site inter-vendor reproducibility of T and T2 measurements of knee cartilage. Methods: 3D magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (3D MAPSS) were implemented on MR systems from Siemens, GE and Philips. Phantom and human subject data were collected at four sites using 3T MR systems from the three vendors with harmonized protocols. Phantom data were collected by means of different positioning of the coil. Volunteers were scanned and rescanned after repositioning. Two traveling volunteers were scanned at all sites. Data were transferred to one site for centralized processing. Results: Intra-site average coefficient of variations (CVs) ranged from 1.09% to 3.05% for T and 1.78–3.30% for T2 in phantoms, and 1.60–3.93% for T and 1.44–4.08% for T2 in volunteers. Inter-site average CVs were 5.23% and 6.45% for MAPSS T and T2, respectively in phantoms, and 8.14% and 10.06% for MAPSS T and T2, respectively, In volunteers. Conclusion: This study showed promising results of multi-site, multi-vendor reproducibility of T and T2 values in knee cartilage. These quantitative measures may be applied in large-scale multi-site, multi-vendor trials with controlled sequence structure and scan parameters and centralized data processing.

Original languageEnglish (US)
Pages (from-to)1539-1550
Number of pages12
JournalOsteoarthritis and Cartilage
Issue number12
StatePublished - Dec 2020


  • Cartilage imaging
  • Magnetic resonance imaging
  • Repeatability
  • Reproducibility
  • T
  • T

ASJC Scopus subject areas

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine


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