mTOR signaling in the hippocampus is necessary for memory formation

Pedro Bekinschtein, Cynthia Katche, Leandro N. Slipczuk, Lionel Müller Igaz, Martín Cammarota, Iván Izquierdo, Jorge H. Medina

Research output: Contribution to journalArticlepeer-review

157 Scopus citations


It is widely accepted that the formation of long-term memory (LTM) requires mRNA translation, but little is known about the cellular mechanisms in the brain that regulate this process. Mammalian target of rapamycin (mTOR) is a key regulator of translational efficacy and capacity. Here, we show that LTM formation of one-trial inhibitory avoidance (IA) in rats, a hippocampus-dependent fear-motivated learning task, requires mTOR activation. IA training is specifically associated with a rapid increase in the phosphorylation state of mTOR and its substrate ribosomal S6 kinase (p70S6K). Bilateral intra-CA1 infusion of rapamycin, a selective mTOR inhibitor, 15 min before, but not immediately after training completely hinders IA LTM without affecting short-term memory (STM) retention. Therefore, our findings indicate that the regulation of hippocampal mRNA translation is a major control step in memory consolidation.

Original languageEnglish (US)
Pages (from-to)303-307
Number of pages5
JournalNeurobiology of Learning and Memory
Issue number2
StatePublished - Feb 2007
Externally publishedYes


  • Hippocampus
  • Memory consolidation
  • Protein synthesis
  • Rapamycin
  • mTOR

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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