MSC niche for hematopoiesis

Daniel Lucas, Sandra Pinho, Paul S. Frenette

Research output: Chapter in Book/Report/Conference proceedingChapter


Blood cell production is maintained throughout life by hematopoietic stem cells (HSC), which reside in specific areas of the bone marrow (BM) referred to as niches. These niches regulate the self-renewal, proliferation, and migration of HSC and also integrate signals from the periphery to respond to the hematopoietic demand. In the last decade, several putative cellular components of the HSC niche have been identified. Here, we briefly review current knowledge on different putative niche cells and their regulation.

Original languageEnglish (US)
Title of host publicationMesenchymal Stromal Cells
Subtitle of host publicationBiology and Clinical Applications
PublisherSpringer New York
Number of pages16
ISBN (Electronic)9781461457114
ISBN (Print)9781461457107
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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