@article{2ba969f5e47346e59b05fd7893a3b8a7,
title = "mRNA Vaccine Effectiveness Against Coronavirus Disease 2019 Hospitalization Among Solid Organ Transplant Recipients",
abstract = "Background: The study objective was to evaluate 2- and 3-dose coronavirus disease 2019 (COVID-19) mRNA vaccine effectiveness (VE) in preventing COVID-19 hospitalization among adult solid organ transplant (SOT) recipients. Methods: We conducted a 21-site case-control analysis of 10 425 adults hospitalized in March to December 2021. Cases were hospitalized with COVID-19; controls were hospitalized for an alternative diagnosis (severe acute respiratory syndrome coronavirus 2-negative). Participants were classified as follows: SOT recipient (n = 440), other immunocompromising condition (n = 1684), or immunocompetent (n = 8301). The VE against COVID-19-associated hospitalization was calculated as 1-adjusted odds ratio of prior vaccination among cases compared with controls. Results: Among SOT recipients, VE was 29% (95% confidence interval [CI], -19% to 58%) for 2 doses and 77% (95% CI, 48% to 90%) for 3 doses. Among patients with other immunocompromising conditions, VE was 72% (95% CI, 64% to 79%) for 2 doses and 92% (95% CI, 85% to 95%) for 3 doses. Among immunocompetent patients, VE was 88% (95% CI, 87% to 90%) for 2 doses and 96% (95% CI, 83% to 99%) for 3 doses. Conclusions: Effectiveness of COVID-19 mRNA vaccines was lower for SOT recipients than immunocompetent adults and those with other immunocompromising conditions. Among SOT recipients, vaccination with 3 doses of an mRNA vaccine led to substantially greater protection than 2 doses.",
keywords = "COVID-19, SARS-CoV-2, immunocompromised, solid organ transplantation, vaccine effectiveness",
author = "{Influenza and Other Viruses in the Acutely Ill (IVY) Network} and Kwon, {Jennie H.} and Tenforde, {Mark W.} and Manjusha Gaglani and Talbot, {H. Keipp} and Ginde, {Adit A.} and Tresa McNeal and Shekhar Ghamande and Douin, {David J.} and Casey, {Jonathan D.} and Mohr, {Nicholas M.} and Anne Zepeski and Shapiro, {Nathan I.} and Gibbs, {Kevin W.} and Files, {D. Clark} and Hager, {David N.} and Arber Shehu and Prekker, {Matthew E.} and Caspers, {Sean D.} and Exline, {Matthew C.} and Mena Botros and Gong, {Michelle N.} and Alex Li and Amira Mohamed and Johnson, {Nicholas J.} and Vasisht Srinivasan and Steingrub, {Jay S.} and Peltan, {Ithan D.} and Brown, {Samuel M.} and Martin, {Emily T.} and Akram Khan and Hough, {Catherine L.} and Busse, {Laurence W.} and Abhijit Duggal and Wilson, {Jennifer G.} and Cynthia Perez and Chang, {Steven Y.} and Christopher Mallow and Randal Rovinski and Babcock, {Hilary M.} and Lauring, {Adam S.} and Laura Felley and Natasha Halasa and Chappell, {James D.} and Grijalva, {Carlos G.} and Rice, {Todd W.} and Womack, {Kelsey N.} and Lindsell, {Christopher J.} and Hart, {Kimberly W.} and Adrienne Baughman and Olson, {Samantha M.}",
note = "Funding Information: Primary funding was provided by the Centers for Disease Control and Prevention (CDC Award 75D30121F00002; to W. H. S.). The REDCap data tool used in this program was funded by Clinical and Translational Science Award UL1 TR002243 from the National Center for Advancing Translational Sciences. Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.",
year = "2022",
month = sep,
day = "1",
doi = "10.1093/infdis/jiac118",
language = "English (US)",
volume = "226",
pages = "797--807",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",
}
