MRI of laser-induced interstitial thermal injury in an in vivo animal liver model with histologic correlation

Paul R. Morrison; Ferenc A. Jolesz; Daniel Charous; Robert V. Mulkern; Stephen G. Hushek; Randall Margolis; Marvin P. Fried

doi:10.1002/jmri.1880080114

MRI of laser-induced interstitial thermal injury in an in vivo animal liver model with histologic correlation

Paul R. Morrison, Ferenc A. Jolesz, Daniel Charous, Robert V. Mulkern, Stephen G. Hushek, Randall Margolis, Marvin P. Fried

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Laser-induced interstitial thermal therapy (LITT) is a preferred method of minimally invasive therapy. MRI is a noninvasive method by which to monitor the thermal effects of LITT. To properly control such effects, changes in MRI parameters during and after LITT should be correlated with changes in the tissue. T1-weighted fast spin echo (FSE) MRI (1 image/10 seconds) at 1.5 T monitored LITT in vivo in rabbit liver (n = 6) using an interstitial bare delivery fiber (600-μm diameter; 3.0 W; 1,064 nm; 150 seconds). During laser irradiation, MRI signal intensity decreased around the fiber tip; after irradiation, this hypointensity proved reversible and permanent lesions were evident. The lesions had hyperintense margins that were brighter than surrounding normal throne (P < .001); the tissue in these bright regions was mapped to tissue necrosis characterized by the presence of thermally damaged ghost red blood cells amid generally normal hepatocytes. T1-FSE identified the spatial extent of the LITT lesions.

Original language	English (US)
Pages (from-to)	57-63
Number of pages	7
Journal	Journal of Magnetic Resonance Imaging
Volume	8
Issue number	1
DOIs	https://doi.org/10.1002/jmri.1880080114
State	Published - Jan 1998
Externally published	Yes

Keywords

Interventional radiology
Laser
MRI
Minimally Invasive therapy
Minimally invasive surgery

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/jmri.1880080114

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title = "MRI of laser-induced interstitial thermal injury in an in vivo animal liver model with histologic correlation",

abstract = "Laser-induced interstitial thermal therapy (LITT) is a preferred method of minimally invasive therapy. MRI is a noninvasive method by which to monitor the thermal effects of LITT. To properly control such effects, changes in MRI parameters during and after LITT should be correlated with changes in the tissue. T1-weighted fast spin echo (FSE) MRI (1 image/10 seconds) at 1.5 T monitored LITT in vivo in rabbit liver (n = 6) using an interstitial bare delivery fiber (600-μm diameter; 3.0 W; 1,064 nm; 150 seconds). During laser irradiation, MRI signal intensity decreased around the fiber tip; after irradiation, this hypointensity proved reversible and permanent lesions were evident. The lesions had hyperintense margins that were brighter than surrounding normal throne (P < .001); the tissue in these bright regions was mapped to tissue necrosis characterized by the presence of thermally damaged ghost red blood cells amid generally normal hepatocytes. T1-FSE identified the spatial extent of the LITT lesions.",

keywords = "Interventional radiology, Laser, MRI, Minimally Invasive therapy, Minimally invasive surgery",

author = "Morrison, {Paul R.} and Jolesz, {Ferenc A.} and Daniel Charous and Mulkern, {Robert V.} and Hushek, {Stephen G.} and Randall Margolis and Fried, {Marvin P.}",

year = "1998",

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doi = "10.1002/jmri.1880080114",

language = "English (US)",

volume = "8",

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journal = "Journal of Magnetic Resonance Imaging",

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AU - Morrison, Paul R.

AU - Jolesz, Ferenc A.

AU - Charous, Daniel

AU - Mulkern, Robert V.

AU - Hushek, Stephen G.

AU - Margolis, Randall

AU - Fried, Marvin P.

PY - 1998/1

Y1 - 1998/1

N2 - Laser-induced interstitial thermal therapy (LITT) is a preferred method of minimally invasive therapy. MRI is a noninvasive method by which to monitor the thermal effects of LITT. To properly control such effects, changes in MRI parameters during and after LITT should be correlated with changes in the tissue. T1-weighted fast spin echo (FSE) MRI (1 image/10 seconds) at 1.5 T monitored LITT in vivo in rabbit liver (n = 6) using an interstitial bare delivery fiber (600-μm diameter; 3.0 W; 1,064 nm; 150 seconds). During laser irradiation, MRI signal intensity decreased around the fiber tip; after irradiation, this hypointensity proved reversible and permanent lesions were evident. The lesions had hyperintense margins that were brighter than surrounding normal throne (P < .001); the tissue in these bright regions was mapped to tissue necrosis characterized by the presence of thermally damaged ghost red blood cells amid generally normal hepatocytes. T1-FSE identified the spatial extent of the LITT lesions.

AB - Laser-induced interstitial thermal therapy (LITT) is a preferred method of minimally invasive therapy. MRI is a noninvasive method by which to monitor the thermal effects of LITT. To properly control such effects, changes in MRI parameters during and after LITT should be correlated with changes in the tissue. T1-weighted fast spin echo (FSE) MRI (1 image/10 seconds) at 1.5 T monitored LITT in vivo in rabbit liver (n = 6) using an interstitial bare delivery fiber (600-μm diameter; 3.0 W; 1,064 nm; 150 seconds). During laser irradiation, MRI signal intensity decreased around the fiber tip; after irradiation, this hypointensity proved reversible and permanent lesions were evident. The lesions had hyperintense margins that were brighter than surrounding normal throne (P < .001); the tissue in these bright regions was mapped to tissue necrosis characterized by the presence of thermally damaged ghost red blood cells amid generally normal hepatocytes. T1-FSE identified the spatial extent of the LITT lesions.

KW - Interventional radiology

KW - Laser

KW - MRI

KW - Minimally Invasive therapy

KW - Minimally invasive surgery

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MRI of laser-induced interstitial thermal injury in an in vivo animal liver model with histologic correlation

Abstract

Keywords

ASJC Scopus subject areas

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