MRI features associated with high likelihood of conversion of radiologically isolated syndrome to multiple sclerosis

Joseph Bisulca; Amy De Lury; Patricia K. Coyle; Olga Syritsyna; Robert Peyster; Lev Bangiyev; Tim Q. Duong

doi:10.1016/j.msard.2019.101381

MRI features associated with high likelihood of conversion of radiologically isolated syndrome to multiple sclerosis

Joseph Bisulca, Amy De Lury, Patricia K. Coyle, Olga Syritsyna, Robert Peyster, Lev Bangiyev, Tim Q. Duong

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Radiologically isolated syndrome (RIS) is the asymptomatic precursor to clinically isolated syndrome, relapsing-remitting multiple sclerosis (MS) or primary progressive MS. RIS is frequently diagnosed when an individual gets an MRI for an unrelated medical issue, such as headache or trauma. Treating RIS patients is controversial, but physicians may be inclined to offer prophylactic treatment for high-risk RIS patients. Identifying imaging and clinical features associated with high likelihood of early clinical conversion may prove helpful to identify a high-risk subset for potential MS therapy. The goal of this paper is to review current literatures to identify imaging and clinical features that predict early (within 5 years) conversion from RIS to MS.

Original language	English (US)
Article number	101381
Journal	Multiple Sclerosis and Related Disorders
Volume	36
DOIs	https://doi.org/10.1016/j.msard.2019.101381
State	Published - Nov 2019
Externally published	Yes

Keywords

Brain T2 lesions
Brain atrophy
Clinically isolated syndrome
Contrast-enhancement
Relapsing-remitting MS
Spinal cord lesions

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "MRI features associated with high likelihood of conversion of radiologically isolated syndrome to multiple sclerosis",

abstract = "Radiologically isolated syndrome (RIS) is the asymptomatic precursor to clinically isolated syndrome, relapsing-remitting multiple sclerosis (MS) or primary progressive MS. RIS is frequently diagnosed when an individual gets an MRI for an unrelated medical issue, such as headache or trauma. Treating RIS patients is controversial, but physicians may be inclined to offer prophylactic treatment for high-risk RIS patients. Identifying imaging and clinical features associated with high likelihood of early clinical conversion may prove helpful to identify a high-risk subset for potential MS therapy. The goal of this paper is to review current literatures to identify imaging and clinical features that predict early (within 5 years) conversion from RIS to MS.",

keywords = "Brain T2 lesions, Brain atrophy, Clinically isolated syndrome, Contrast-enhancement, Relapsing-remitting MS, Spinal cord lesions",

author = "Joseph Bisulca and {De Lury}, Amy and Coyle, {Patricia K.} and Olga Syritsyna and Robert Peyster and Lev Bangiyev and Duong, {Tim Q.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = nov,

doi = "10.1016/j.msard.2019.101381",

language = "English (US)",

volume = "36",

journal = "Multiple Sclerosis and Related Disorders",

issn = "2211-0348",

publisher = "Elsevier",

}

TY - JOUR

T1 - MRI features associated with high likelihood of conversion of radiologically isolated syndrome to multiple sclerosis

AU - Bisulca, Joseph

AU - De Lury, Amy

AU - Coyle, Patricia K.

AU - Syritsyna, Olga

AU - Peyster, Robert

AU - Bangiyev, Lev

AU - Duong, Tim Q.

PY - 2019/11

Y1 - 2019/11

N2 - Radiologically isolated syndrome (RIS) is the asymptomatic precursor to clinically isolated syndrome, relapsing-remitting multiple sclerosis (MS) or primary progressive MS. RIS is frequently diagnosed when an individual gets an MRI for an unrelated medical issue, such as headache or trauma. Treating RIS patients is controversial, but physicians may be inclined to offer prophylactic treatment for high-risk RIS patients. Identifying imaging and clinical features associated with high likelihood of early clinical conversion may prove helpful to identify a high-risk subset for potential MS therapy. The goal of this paper is to review current literatures to identify imaging and clinical features that predict early (within 5 years) conversion from RIS to MS.

AB - Radiologically isolated syndrome (RIS) is the asymptomatic precursor to clinically isolated syndrome, relapsing-remitting multiple sclerosis (MS) or primary progressive MS. RIS is frequently diagnosed when an individual gets an MRI for an unrelated medical issue, such as headache or trauma. Treating RIS patients is controversial, but physicians may be inclined to offer prophylactic treatment for high-risk RIS patients. Identifying imaging and clinical features associated with high likelihood of early clinical conversion may prove helpful to identify a high-risk subset for potential MS therapy. The goal of this paper is to review current literatures to identify imaging and clinical features that predict early (within 5 years) conversion from RIS to MS.

KW - Brain T2 lesions

KW - Brain atrophy

KW - Clinically isolated syndrome

KW - Contrast-enhancement

KW - Relapsing-remitting MS

KW - Spinal cord lesions

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U2 - 10.1016/j.msard.2019.101381

DO - 10.1016/j.msard.2019.101381

M3 - Review article

C2 - 31518773

AN - SCOPUS:85072046787

SN - 2211-0348

VL - 36

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

M1 - 101381

ER -

MRI features associated with high likelihood of conversion of radiologically isolated syndrome to multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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