Moving aggressively: S100A4 and tumor invasion

Reniqua P. House; Sarah C. Garrett; Anne R. Bresnick

doi:10.1007/978-94-007-2558-4_4

Moving aggressively: S100A4 and tumor invasion

Reniqua P. House, Sarah C. Garrett, Anne R. Bresnick

Biochemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Tumor cell invasion and metastasis are complex multi-step cellular -processes that involve the ability of malignant cells to escape the primary tumor, migrate to distant sites within the body and establish secondary tumors. S100A4, a member of the S100 family of Ca²⁺-binding proteins, is a prognostic marker in a number of human cancers and has a direct role in promoting metastatic disease. S100A4's metastasis promoting properties are attributed to diverse biological -functions including the regulation of apoptosis, cell motility, invasion and angiogenesis. In this chapter we discuss the contribution of tumor and stromal-derived S100A4 in supporting metastatic dissemination and examine the biochemical properties of S100A4 and the S100A4/target protein interactions that may contribute to its function as a metastasis factor.

Original language	English (US)
Title of host publication	Signaling Pathways and Molecular Mediators in Metastasis
Publisher	Springer Netherlands
Pages	91-113
Number of pages	23
Volume	9789400725584
ISBN (Electronic)	9789400725584
ISBN (Print)	9400725574, 9789400725577
DOIs	https://doi.org/10.1007/978-94-007-2558-4_4
State	Published - Jan 1 2012

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-94-007-2558-4_4

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AB - Tumor cell invasion and metastasis are complex multi-step cellular -processes that involve the ability of malignant cells to escape the primary tumor, migrate to distant sites within the body and establish secondary tumors. S100A4, a member of the S100 family of Ca2+-binding proteins, is a prognostic marker in a number of human cancers and has a direct role in promoting metastatic disease. S100A4's metastasis promoting properties are attributed to diverse biological -functions including the regulation of apoptosis, cell motility, invasion and angiogenesis. In this chapter we discuss the contribution of tumor and stromal-derived S100A4 in supporting metastatic dissemination and examine the biochemical properties of S100A4 and the S100A4/target protein interactions that may contribute to its function as a metastasis factor.

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M3 - Chapter

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Moving aggressively: S100A4 and tumor invasion

Abstract

ASJC Scopus subject areas

UN SDGs

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