Moving aggressively: S100A4 and tumor invasion

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Tumor cell invasion and metastasis are complex multi-step cellular -processes that involve the ability of malignant cells to escape the primary tumor, migrate to distant sites within the body and establish secondary tumors. S100A4, a member of the S100 family of Ca2+-binding proteins, is a prognostic marker in a number of human cancers and has a direct role in promoting metastatic disease. S100A4's metastasis promoting properties are attributed to diverse biological -functions including the regulation of apoptosis, cell motility, invasion and angiogenesis. In this chapter we discuss the contribution of tumor and stromal-derived S100A4 in supporting metastatic dissemination and examine the biochemical properties of S100A4 and the S100A4/target protein interactions that may contribute to its function as a metastasis factor.

Original languageEnglish (US)
Title of host publicationSignaling Pathways and Molecular Mediators in Metastasis
PublisherSpringer Netherlands
Number of pages23
ISBN (Electronic)9789400725584
ISBN (Print)9400725574, 9789400725577
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)


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