Mouse models of follicular and papillary thyroid cancer progression

Marika A. Russo; Valeria G.Antico Arciuch; Antonio Di Cristofano

doi:10.3389/fendo.2011.00119

Mouse models of follicular and papillary thyroid cancer progression

Marika A. Russo, Valeria G.Antico Arciuch, Antonio Di Cristofano

Developmental & Molecular Biology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

A significant number of well-differentiated thyroid cancers progress or recur, becoming resistant to current therapeutic options. Mouse models recapitulating the genetic and histological features of advanced thyroid cancer have been an invaluable tool to dissect the mechanisms involved in the progression from indolent, well differentiated tumors to aggressive, poorly differentiated carcinomas, and to identify novel therapeutic targets. In this review, we focus on the lessons learned from models of epithelial cell-derived thyroid cancer showing progression from hyperplastic lesions to locally invasive and metastatic carcinomas.

Original language	English (US)
Article number	Article 119
Journal	Frontiers in Endocrinology
Volume	3
Issue number	JAN
DOIs	https://doi.org/10.3389/fendo.2011.00119
State	Published - 2012

Keywords

Cancer
Mouse
Progression
Thyroid

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fendo.2011.00119

Cite this

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abstract = "A significant number of well-differentiated thyroid cancers progress or recur, becoming resistant to current therapeutic options. Mouse models recapitulating the genetic and histological features of advanced thyroid cancer have been an invaluable tool to dissect the mechanisms involved in the progression from indolent, well differentiated tumors to aggressive, poorly differentiated carcinomas, and to identify novel therapeutic targets. In this review, we focus on the lessons learned from models of epithelial cell-derived thyroid cancer showing progression from hyperplastic lesions to locally invasive and metastatic carcinomas.",

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T1 - Mouse models of follicular and papillary thyroid cancer progression

AU - Russo, Marika A.

AU - Arciuch, Valeria G.Antico

AU - Di Cristofano, Antonio

PY - 2012

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N2 - A significant number of well-differentiated thyroid cancers progress or recur, becoming resistant to current therapeutic options. Mouse models recapitulating the genetic and histological features of advanced thyroid cancer have been an invaluable tool to dissect the mechanisms involved in the progression from indolent, well differentiated tumors to aggressive, poorly differentiated carcinomas, and to identify novel therapeutic targets. In this review, we focus on the lessons learned from models of epithelial cell-derived thyroid cancer showing progression from hyperplastic lesions to locally invasive and metastatic carcinomas.

AB - A significant number of well-differentiated thyroid cancers progress or recur, becoming resistant to current therapeutic options. Mouse models recapitulating the genetic and histological features of advanced thyroid cancer have been an invaluable tool to dissect the mechanisms involved in the progression from indolent, well differentiated tumors to aggressive, poorly differentiated carcinomas, and to identify novel therapeutic targets. In this review, we focus on the lessons learned from models of epithelial cell-derived thyroid cancer showing progression from hyperplastic lesions to locally invasive and metastatic carcinomas.

KW - Cancer

KW - Mouse

KW - Progression

KW - Thyroid

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JF - Frontiers in Endocrinology

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ER -

Mouse models of follicular and papillary thyroid cancer progression

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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