Morphine-augmented hepatobiliary scintigraphy: A meta-analysis

M. D. Cabana, A. Alavi, J. A. Berlin, J. A. Shea, C. K. Kim, S. V. Williams

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The aim of this study was to compare the sensitivity and specificity of morphine-augmented hepatobiliary scintigraphy (MA-HBS) with that of conventional hepatobiliary scintigraphy (C-HBS) for acute cholecystitis. The results of most MA-HBS studies cannot be compared with C-HBS estimates, since articles describing C-HBS often include non-candidates for MA-HBS. However, using meta-analytic techniques to combine data from eligible studies (4 for C-HBS and 5 for MA-HBS), the specificity of MA-HBS (0.84; 95% Cl = 0.75-0.94) was significantly greater (P = 0.008) than that of C-HBS (0.68; 95% Cl = 0.61-0.75); there were no differences in sensitivity (MA-HBS: 0.96, 95% Cl = 0.92-0.99; C-HBS: 0.97, 95% Cl = 0.97-0.99.

Original languageEnglish (US)
Pages (from-to)1068-1071
Number of pages4
JournalNuclear Medicine Communications
Issue number12
StatePublished - Dec 1995
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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