The hybridoma technology has made it possible to generate superior serological reagents in large amounts and to have the same reagents available indefinitely. Such monoclonal antibodies are very useful in diagnosis and epidemiology. Monoclonals have also made it possible to identify the sequences on infectious agents that are responsible for their infectivity and to generate and study both polypeptide and idiotypic vaccines. Once human monoclonals can be easily generated and produced, passive immunization may again become a major therapeutic tool.
ASJC Scopus subject areas
- Microbiology (medical)