Monitoring of specific antibodies to human immunodeficiency virus structural proteins: Clinical significance

Jean Pierre Allain; Yves Laurian; Mark H. Einstein; Brian P. Braun; Stephen R. Delaney; John E. Stephens; Cynthia K. Daluga; Stephen J. Dahlen; Kevin M. Knigge

Monitoring of specific antibodies to human immunodeficiency virus structural proteins: Clinical significance

Jean Pierre Allain, Yves Laurian, Mark H. Einstein, Brian P. Braun, Stephen R. Delaney, John E. Stephens, Cynthia K. Daluga, Stephen J. Dahlen, Kevin M. Knigge

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Levels of antibodies to six major structural proteins of human immunodeficiency virus type 1 (gp120, gp41, p66, p31, p24, and p17) were assessed in serial samples from 22 persons with severe hemophilia (16 asymptomatic and 6 who developed acquired immunodeficiency syndrome [AIDS] or AIDS-related complex) with an automated dot blot assay using purified recombinant antigens. High and sustained levels of antibody to gp120, gp41, and p31 were found in all patients irrespective of their clinical condition for 4 to 6 years after seroconversion. In contrast, immune response to p66 and p17 was significantly lower in symptomatic patients. Over time, the levels of these two antibodies, as well as anti-p24, decreased and tended to become undetectable. Abnormal immune response and low levels of antibody to p66 and p17 are early indications of rapid clinical progression.

Original language	English (US)
Pages (from-to)	1118-1123
Number of pages	6
Journal	Blood
Volume	77
Issue number	5
State	Published - Mar 1 1991
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Monitoring of specific antibodies to human immunodeficiency virus structural proteins: Clinical significance",

abstract = "Levels of antibodies to six major structural proteins of human immunodeficiency virus type 1 (gp120, gp41, p66, p31, p24, and p17) were assessed in serial samples from 22 persons with severe hemophilia (16 asymptomatic and 6 who developed acquired immunodeficiency syndrome [AIDS] or AIDS-related complex) with an automated dot blot assay using purified recombinant antigens. High and sustained levels of antibody to gp120, gp41, and p31 were found in all patients irrespective of their clinical condition for 4 to 6 years after seroconversion. In contrast, immune response to p66 and p17 was significantly lower in symptomatic patients. Over time, the levels of these two antibodies, as well as anti-p24, decreased and tended to become undetectable. Abnormal immune response and low levels of antibody to p66 and p17 are early indications of rapid clinical progression.",

author = "Allain, {Jean Pierre} and Yves Laurian and Einstein, {Mark H.} and Braun, {Brian P.} and Delaney, {Stephen R.} and Stephens, {John E.} and Daluga, {Cynthia K.} and Dahlen, {Stephen J.} and Knigge, {Kevin M.}",

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language = "English (US)",

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T1 - Monitoring of specific antibodies to human immunodeficiency virus structural proteins

T2 - Clinical significance

AU - Allain, Jean Pierre

AU - Laurian, Yves

AU - Einstein, Mark H.

AU - Braun, Brian P.

AU - Delaney, Stephen R.

AU - Stephens, John E.

AU - Daluga, Cynthia K.

AU - Dahlen, Stephen J.

AU - Knigge, Kevin M.

PY - 1991/3/1

Y1 - 1991/3/1

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AB - Levels of antibodies to six major structural proteins of human immunodeficiency virus type 1 (gp120, gp41, p66, p31, p24, and p17) were assessed in serial samples from 22 persons with severe hemophilia (16 asymptomatic and 6 who developed acquired immunodeficiency syndrome [AIDS] or AIDS-related complex) with an automated dot blot assay using purified recombinant antigens. High and sustained levels of antibody to gp120, gp41, and p31 were found in all patients irrespective of their clinical condition for 4 to 6 years after seroconversion. In contrast, immune response to p66 and p17 was significantly lower in symptomatic patients. Over time, the levels of these two antibodies, as well as anti-p24, decreased and tended to become undetectable. Abnormal immune response and low levels of antibody to p66 and p17 are early indications of rapid clinical progression.

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Monitoring of specific antibodies to human immunodeficiency virus structural proteins: Clinical significance

Abstract

ASJC Scopus subject areas

UN SDGs

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